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MDHA produced by both stromal and thylakoid bound APX isoforms is reduced by stromal MDHAR

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All experiments were conducted in triplicate

Liver metabolism during glucouronidation or sulfation, CYP activity and maintenance of hepatic GSH supply depends on patient factors such as age, nutritional status, pre-existing liver disease, concurrent use of alcohol and other liver-metabolized medications, genetic predispositions, and most importantly, the acuity or chronicity of APAP overuse